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— Muzaffaruddin Alvi (@Muzaffar1969) December 19, 2017
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#BoardOfDirectors Jim Eason joins Bower & Branch board of directors – Jim Eason joins Bower & Branch board of directors Nursery ManagementFull coverage http://bit.ly/2yWsQac
— Muzaffaruddin Alvi (@Muzaffar1969) December 19, 2017
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#BoardOfDirectors Rowayton resident, Greg Bauer, joins KEYS Board of Directors http://bit.ly/2igNsr6
— Muzaffaruddin Alvi (@Muzaffar1969) November 29, 2017
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#BoardOfDirectors Stock Repurchase Plan Declared by Avnet (NYSE:AVT) Board of Directors http://bit.ly/2zrarDo
— Muzaffaruddin Alvi (@Muzaffar1969) November 27, 2017
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#BoardOfDirectors FLY Yoga Outreach announces board of directors http://bit.ly/2BpEn3Z
— Muzaffaruddin Alvi (@Muzaffar1969) November 27, 2017
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Silicon Valley is not known for its diversity. And its ‘brotown’ image is not helped by the too-frequent horror stories that come out of the companies based there.
June 05, 2017 at 09:58AM
from George Nott
The Nation |
Solar tubewell financing scheme on the cards
The Nation Official sources, while listing initiatives taken by State Bank of Pakistan (SBP) for financial inclusion in agriculture financing during this year, on Sunday said that in order to simplify lending process for agriculture financing, revised loan … |
June 05, 2017 at 10:01AM
from
Telstra is set to cut up to 87 jobs due to the ongoing restructure of its Enterprise Services business.
June 05, 2017 at 09:58AM
from Leon Spencer
Publication date: Available online 3 June 2017
Source:Artificial Intelligence in Medicine
Author(s): Xiangyi Li, Yingjie Xu, Hui Cui, Tao Huang, Disong Wang, Baofeng Lian, Wei Li, Guangrong Qin, Lanming Chen, Lu Xie
ObjectiveSynergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as drug response, and target networks may contribute to prediction of synergistic drug combinations. In this study, we aimed to construct a computational model to predict synergistic drug combinations.MethodsWe designed drug physicochemical features and network features, including drug chemical structure similarity, target distance in protein–protein network and targeted pathway similarity. At the same time, we designed fifteen pharmacogenomics features using drug treated gene expression profiles based on the background of cancer-related biology network. Based on these eighteen features, we built a prediction model for Synergistic Drug combination using Random forest algorithm (SyDRa).ResultsOur model achieved a quite good performance with AUC value of 0.89 and Out-of-bag estimate error rate of 0.15 in training dataset. Using the random anti-cancer drug combinations which have transcriptional profile data in the Connectivity Map dataset as the testing dataset, we identified 28 potentially synergistic drug combinations, three out of which had been reported to be effective drug combinations by literatures.ConclusionsWe studied eighteen features for drug combinations and built a computational model using random forest algorithm. The model was evaluated using an independent test dataset. Our model provides an efficient strategy to identify potentially synergistic drug combinations for cancer and may help reduce the search space for high-throughput synergistic drug combinations screening.
June 04, 2017 at 08:58AM
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AIDINDIA retweeted:
#Board #Management Dialogue on #Risk Appetite buff.ly/2rI0VLj @NACD #corpgov #CEO #CFO #BoardofDirectors #AuditCommittee #ERM #GRC
May 29, 2017 at 09:55AM
https://twitter.com/AIDIndia3/status/869050856506839041
from AIDINDIA
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AIDINDIA retweeted:
Why your #board should refocus on key #risks buff.ly/2rZrgBZ @CFOdirect #corpgov #CEO #CFO #Board #BoardofDirectors #AuditCommittee
May 29, 2017 at 09:55AM
https://twitter.com/AIDIndia3/status/869050842476892161
from AIDINDIA
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César Amezcua retweeted:
Why your #board should refocus on key #risks buff.ly/2rZrgBZ @CFOdirect #corpgov #CEO #CFO #Board #BoardofDirectors #AuditCommittee
May 29, 2017 at 09:55AM
https://twitter.com/CASFinance2017/status/869049997584605184
from César Amezcua
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César Amezcua retweeted:
#Board #Management Dialogue on #Risk Appetite buff.ly/2rI0VLj @NACD #corpgov #CEO #CFO #BoardofDirectors #AuditCommittee #ERM #GRC
May 29, 2017 at 09:55AM
https://twitter.com/CASFinance2017/status/869049752037412864
from César Amezcua
